Sepoy-logo
No Result
View All Result
Wednesday, February 8, 2023
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
No Result
View All Result
SEPOY.NET
No Result
View All Result
Home Health

Absolute vaccine effectiveness for third and fourth doses of mRNA COVID-19 vaccine against Omicron

Nicholas by Nicholas
August 24, 2022
in Health
0

In a recent study posted to the medRxiv* preprint server, researchers analyzed the efficacy of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) fourth-dose vaccination relative to no vaccination towards the Omicron BA.1 variant.

Study: Effectiveness of fourth dose COVID-19 vaccine against the Omicron variant compared to no vaccination. Image Credit: luchschenF/Shutterstock

Background

Global coronavirus disease 2019 (COVID-19) prevention strategies have been hampered significantly by the waning SARS-CoV-2 vaccine effectiveness (VE) and the ability of the SARS-CoV-2 Omicron variant to escape pre-existent immunity. Several nations have launched fourth-dose COVID-19 vaccination programs in response to this.

Relative VE (rVE) towards Omicron following the latest messenger ribonucleic acid (mRNA)-based fourth dose vaccination versus a third shot given around four months earlier has been documented in published trials in people aged 60 years or older. Interestingly, just one study reported VE of the fourth dose compared to no vaccination, which the present study’s authors refer to as absolute VE (aVE). Nevertheless, third and fourth-dose aVE for equivalent time durations is unavailable.

About the study

In the current work, the researchers sought to determine the three-dose and four-dose SARS-CoV-2 vaccine series aVE at the same point after vaccination. They calculated the aVE for the third and fourth doses of COVID-19 mRNA vaccine compared to receiving no vaccination towards Omicron, considering clinical outcome utilizing a set of logistic regression equations and VE estimations for a fourth dosage compared to a third dose described in an Israeli investigation.

Based on information from the United Kingdom Health Security Agency (UKHSA), the authors previously released a logistic regression equation that forecasts aVE, including waning with time, for the third COVID-19 mRNA vaccine dose irrespective of the initial course, against symptomatic infection and hospitalization associated with Omicron. Further, they used a study that reported VE per age against the SARS-CoV-2 Delta variant to expand this equation to account for age variability in VE.

Moreover, the team included the other outcomes of symptomatic and asymptomatic infection, as well as death, leveraging information provided by the UKHSA, to develop a set of equations that estimates the VE of the third dose against Omicron BA.1 variant according to age, the severity of the illness, and the time post-vaccination. Subsequently, they adapted these equations to approximate the aVE of the third dose three weeks after vaccination. The authors transformed Magen et al.’ documented fourth dose rVE to fourth dose aVE estimates three weeks post-vaccination presuming a median gap of 20 weeks between the third and fourth vaccine doses in the Magen et al. research.

Furthermore, the expected aVE readings and their unpredictability intervals were calculated with 10,000 repetitions of Monte Carlo simulation, reproducing uncertainty in the observed rVE of the fourth dose and the scientists’ logistic equation estimations of a third dose aVE.

Limitations

The following are the limitations of the study’s approach.

1) The investigators extrapolated UKHSA information onto Israeli information under the assumption that a third shot of the vaccine in Israel would have the same waning effect as one in the UK. Nonetheless, considering the lack of experiments that directly compare persons getting the third and fourth doses at the same timeframe, each matched to those with no previous infection or vaccination, these hypotheses seem acceptable. Besides, it was challenging to envision a substitute technique to assess aVE.

2) The current estimates were based on the VE against the Omicron BA.1 subvariant. Immune evasion may result in decreased fourth dose aVE towards newer SARS-CoV-2 subvariants. Yet, the researchers anticipate that the trends they predict of restored or even slightly heightened aVE post a fourth shot will likely retain.

Results and conclusions

The research findings suggested that aVE after a fourth dose COVID-19 mRNA vaccination schedule was higher and associated with more severe clinical outcomes similar to a three-dose. The team discovered that a fourth dose of the SARS-CoV-2 mRNA vaccine reinstates or even improves the protection provided by a third dose within the same timeframe following vaccination.

For symptomatic SARS-CoV-2 infection and any infection at the same period post-vaccination, estimated aVE after a fourth dose seems greater than following the third dose, albeit uncertainty intervals coincided. In addition, the authors anticipated that policymakers assessing the costs and advantages of the fourth SARS-CoV-2 vaccine doses would be interested in the present estimations.

*Important notice

medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.

READ ALSO

The Pill Club reaches $18.3 million Medicaid fraud settlement with California

Symptomatic SARS-CoV-2 infection during pregnancy increases risk of complications for mother and infant

Tags: CoronavirusCoronavirus Disease COVID-19covid-19EfficacyimmunityOmicronResearchRespiratoryRibonucleic AcidSARSSARS-CoV-2Severe Acute RespiratorySevere Acute Respiratory SyndromeSyndromeVaccine

Related Posts

The Pill Club reaches .3 million Medicaid fraud settlement with California
Health

The Pill Club reaches $18.3 million Medicaid fraud settlement with California

February 8, 2023
Symptomatic SARS-CoV-2 infection during pregnancy increases risk of complications for mother and infant
Health

Symptomatic SARS-CoV-2 infection during pregnancy increases risk of complications for mother and infant

February 7, 2023
The nature of the immune responses induced by various COVID-19 vaccines developed using different platforms and formulations
Health

The nature of the immune responses induced by various COVID-19 vaccines developed using different platforms and formulations

February 7, 2023
Development and testing of a machine-learning-based system for early prediction of antimicrobial susceptibility probability
Health

Development and testing of a machine-learning-based system for early prediction of antimicrobial susceptibility probability

February 7, 2023
VUMC’s Shed-MEDS protocol reduces exposure to potentially inappropriate medications
Health

VUMC’s Shed-MEDS protocol reduces exposure to potentially inappropriate medications

February 7, 2023
How did human mobility affect COVID-19 case growth?
Health

How did human mobility affect COVID-19 case growth?

February 6, 2023
Next Post

5 Letter Ending Words In En Some 5 letters words that end in En

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

POPULAR NEWS

Roblox Is Unbreakable Trello Is this safe?

Roblox Is Unbreakable Trello Is this safe?

November 4, 2022
Discord Registered Games  Discord Registered Gaming You need to join the Club

Discord Registered Games Discord Registered Gaming You need to join the Club

November 4, 2022
How To Chose the Right Data Analytics Program

How To Chose the Right Data Analytics Program

November 4, 2022
Chandrashekhar Guruji Wiki, Age, Girlfriend, Wife, Family, Biography & More

Chandrashekhar Guruji Wiki, Age, Girlfriend, Wife, Family, Biography & More

November 4, 2022
Heavy explosion on market square in Halle – three injured

Heavy explosion on market square in Halle – three injured

November 4, 2022

EDITOR'S PICK

Photographer William Klein has died

September 13, 2022
Body donors: why university hospitals need corpses for teaching

Body donors: why university hospitals need corpses for teaching

November 11, 2022
Analyse on-chain du Bitcoin (BTC) – Les HODLers cèdent face à la pression ?

Analyse on-chain du Bitcoin (BTC) – Les HODLers cèdent face à la pression ?

November 29, 2022

Aditi Saigal (Dot.) Wiki, Age, Boyfriend, Husband, Children, Family, Biography & More

May 18, 2022

About

Sepoy.net is a perfect place for people who want daily updates on news related to business, technology, entertainment, health, cryptocurrency etc.

Contact: [email protected]

Major Categories

News

Business

Tech

Economy

 

Recent Posts

  • The Pill Club reaches $18.3 million Medicaid fraud settlement with California
  • Volkswagen operating profit increases
  • The Benefits of Investing in Aluminium Plantation Shutters

Pages

  • About Us
  • Contact Us
  • Disclaimer
  • DMCA
  • Home
  • Privacy Policy

© 2023 Sepoy.net

No Result
View All Result
  • Home
  • Business
  • News
  • Health
  • Tech
  • Science
  • Lifestyle
  • Travel

© 2023 Sepoy.net