Sepoy-logo
No Result
View All Result
Tuesday, February 7, 2023
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
No Result
View All Result
SEPOY.NET
No Result
View All Result
Home Health

Human T cell immunity is coping with mutations in SARS-CoV-2 variants of concern

Nicholas by Nicholas
December 2, 2022
in Health
0
Human T cell immunity is coping with mutations in SARS-CoV-2 variants of concern

Immune T cells are continuing to target the spike protein of SARS-CoV-2 variants of concern, although mutations are making some T cells less effective, according to new research.

Published in Nature Immunology, researchers from the University of Birmingham have shown that human T cell immunity is currently coping with mutations that have accumulated over time in COVID-19 variants.

In the study, funded by the National Institute for Health and Care Research, the research partner of the NHS, the researchers tested CD4+ T cells collected at the start of the pandemic from healthcare workers infected with COVID-19.

Some of the T-cells were still able to recognize parts of the spike protein, called epitopes, unaltered in later virus strains including the current Omicron variant. However, T cell recognition was worse against seven out of ten epitopes mutated in different variants of concern.

The researchers caution that as SARS-CoV-2 continues to mutate, T-cell recognition of additional epitopes could be lost decreasing overall protection by the immune system.

Dr Heather Long, Associate Professor in the Institute of Immunology and Immunotherapy at the University of Birmingham and lead author of the research said:

“Our paper shows that although most people have a diverse T cell response against the virus, some responses are less effective against Omicron. As further variants of concern are identified we will need to consider carefully how new viral mutations affect T-cell recognition.”

The vaccines currently in use are still vital to protect us from COVID-19. Should SARS-CoV-2 continue to mutate to evade the immune system, our findings will help researchers to develop new vaccines better suited to those variants.”


Dr Graham Taylor, Associate Professor, Institute of Immunology and Immunotherapy, University of Birmingham

Source:

Journal reference:

Tye, E.X.C., et al. (2022) Mutations in SARS-CoV-2 spike protein impair epitope-specific CD4+ T cell recognition. Nature Immunology. doi.org/10.1038/s41590-022-01351-7.

READ ALSO

Development and testing of a machine-learning-based system for early prediction of antimicrobial susceptibility probability

VUMC’s Shed-MEDS protocol reduces exposure to potentially inappropriate medications

Tags: CD4Cellcovid-19Immune SystemimmunityImmunologyImmunotherapyOmicronProteinResearchSARSSARS-CoV-2Spike ProteinT-CellVirus

Related Posts

Development and testing of a machine-learning-based system for early prediction of antimicrobial susceptibility probability
Health

Development and testing of a machine-learning-based system for early prediction of antimicrobial susceptibility probability

February 7, 2023
VUMC’s Shed-MEDS protocol reduces exposure to potentially inappropriate medications
Health

VUMC’s Shed-MEDS protocol reduces exposure to potentially inappropriate medications

February 7, 2023
How did human mobility affect COVID-19 case growth?
Health

How did human mobility affect COVID-19 case growth?

February 6, 2023
AAHI awarded a .9 million project to develop prototype intranasal bivalent influenza RNA vaccine candidate
Health

AAHI awarded a $9.9 million project to develop prototype intranasal bivalent influenza RNA vaccine candidate

February 6, 2023
Why two states remain holdouts on distracted driving laws
Health

Why two states remain holdouts on distracted driving laws

February 6, 2023
Virus Watch: A cohort study of COVID-19 in households of England and Wales
Health

Virus Watch: A cohort study of COVID-19 in households of England and Wales

February 6, 2023
Next Post
LSHTM researchers launch new global health research group on HIV-associated fungal infections

LSHTM researchers launch new global health research group on HIV-associated fungal infections

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

POPULAR NEWS

Roblox Is Unbreakable Trello Is this safe?

Roblox Is Unbreakable Trello Is this safe?

November 4, 2022
Discord Registered Games  Discord Registered Gaming You need to join the Club

Discord Registered Games Discord Registered Gaming You need to join the Club

November 4, 2022
How To Chose the Right Data Analytics Program

How To Chose the Right Data Analytics Program

November 4, 2022
Chandrashekhar Guruji Wiki, Age, Girlfriend, Wife, Family, Biography & More

Chandrashekhar Guruji Wiki, Age, Girlfriend, Wife, Family, Biography & More

November 4, 2022
Heavy explosion on market square in Halle – three injured

Heavy explosion on market square in Halle – three injured

November 4, 2022

EDITOR'S PICK

Even Greta Thunberg is for longer terms

October 11, 2022

US Grand Prix: Sainz takes pole after Mateschitz’s death in Texas

October 22, 2022

AHA News: She Thought She Had Bronchitis, But the Problem Was Her Heart

June 15, 2022
A Guide to Buying Indian Gold Chains

A Guide to Buying Indian Gold Chains

January 20, 2023

About

Sepoy.net is a perfect place for people who want daily updates on news related to business, technology, entertainment, health, cryptocurrency etc.

Contact: [email protected]

Major Categories

News

Business

Tech

Economy

 

Recent Posts

  • Development and testing of a machine-learning-based system for early prediction of antimicrobial susceptibility probability
  • Inflation in Argentina: a new 2000 peso note had to be created
  • Earthquake death toll rises to more than 4,200

Pages

  • About Us
  • Contact Us
  • Disclaimer
  • DMCA
  • Home
  • Privacy Policy

© 2023 Sepoy.net

No Result
View All Result
  • Home
  • Business
  • News
  • Health
  • Tech
  • Science
  • Lifestyle
  • Travel

© 2023 Sepoy.net