By Alan Mozes HealthDay Reporter
FRIDAY, Might 13, 2022 (HealthDay Information)
Even earlier than the pandemic, the demand for donor kidneys far exceeded provide. That shortfall solely worsened when hospitals began refusing to make use of kidneys from COVID-positive donors.
Nevertheless, new analysis now means that kidneys from deceased COVID-19 sufferers have virtually zero danger of viral transmission to the recipient:
Within the new research, out of 55 sufferers who obtained such a kidney, none developed COVID-19 after transplant.
“The necessity for organs may be very extreme,” famous research writer Dr. Alvin Wee, a urologist with the Cleveland Clinic’s transplantation middle.
“Even with a report variety of transplants within the U.S. for 2021, there are nonetheless extra individuals who want lifesaving organs,” Wee famous, with solely 20,000 kidney transplants carried out every year and 90,000 sufferers in want.
However the excellent news is that the investigation exhibits that “utilizing kidneys from COVID-positive donors is protected,” Wee added.
Previous to the research, there was an actual concern that kidney donations from a COVID-positive supply may pose a transmission danger, the investigators stated, even supposing there was no arduous proof displaying that the virus might be unfold by way of both urine or blood.
The entire sufferers enrolled within the research — together with 36 males and 19 girls — underwent a kidney transplant on the Cleveland Clinic in some unspecified time in the future between February and October 2021, in the course of the second yr of the pandemic.
Previous to February 2021, Cleveland Clinic had prohibited all donations from COVID-positive sufferers. Solely with the launch of the research had been COVID-positive donors thought of, and solely — at first — from COVID-positive donors who had died from one thing apart from COVID-19. In a while, the donation pool was expanded to incorporate sufferers who had been severely sick with COVID-19 earlier than dying.
On the time of transplantation, about two-thirds of the recipients had been on dialysis. About two-thirds had additionally been vaccinated towards COVID-19 with a full two-dose routine.
On the flip aspect, all 34 donor sufferers had been recognized with COVID-19 at the least as soon as in the course of the 11 weeks previous their dying.
The outcome: Following surgical procedure, not one of the donor recipients examined optimistic for COVID-19. And 14 weeks post-surgery, all of the transplanted kidneys had been discovered to be functioning nicely.
Wee characterised the outcomes as “very optimistic” throughout.
On the one hand, “we’re in a position to transplant extra individuals,” he stated. “[And] on the donor aspect — for households of those sufferers who died from COVID-19 — the donation and utilization of those lifesaving organs provides which means to this mindless dying that’s caused by this pandemic.”
Wee and his colleagues are scheduled to current their findings this week on the American Urological Affiliation’s annual assembly, in New Orleans. Such analysis is taken into account preliminary till revealed in a peer-reviewed journal.
Considerations over the potential danger for recipient an infection is nothing new on this planet of organ transplantation, famous Dr. Brian Inouye, chief resident within the division of urology at Duke College in Durham, N.C.
Although not concerned within the research, Inouye defined that present tips “require donors to be examined for HIV, hepatitis B [HBV] and C [HCV], syphilis, cytomegalovirus, Epstein-Barr virus, toxoplasmosis and, generally, tuberculosis.”
Donations from sufferers with “infamous high-risk viruses” — resembling HIV, HBV, and HCV — had at one level been barred, Inouye famous. However recognizing the dire want for organs, new steering permits physicians “to make use of these once-restricted organs” beneath sure situations, resembling providing HIV-positive recipients organs from an HIV-positive donor.
And the newest findings counsel this strategy may additionally work within the context of COVID-19, “so long as the donor medical historical past is understood and shared with the organ-procurement group, transplantation facilities and recipient. Then the recipient, together with the steering of their transplant group, is allowed the autonomy to make the selection about accepting an organ,” Inouye defined.
There’s extra detailed data on kidney donations on the Nationwide Kidney Basis.
SOURCES: Alvin Wee, MD, urologist, transplantation middle, Cleveland Clinic; Brian Inouye, MD, chief resident, division of urology, Duke College Faculty of Drugs, Durham, N.C.; American Urological Affiliation assembly, New Orleans, Might 13 to 16, 2022
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