Sepoy-logo
No Result
View All Result
Wednesday, March 29, 2023
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
No Result
View All Result
SEPOY.NET
No Result
View All Result
Home Health

New research could be the first step in better targeting breast cancer treatment

Nicholas by Nicholas
November 23, 2022
in Health
0
New research could be the first step in better targeting breast cancer treatment

Researchers have identified a protein that, when present in high amounts in breast cancer tumors, is an indicator of whether DNA-damaging therapies will work or not.

Lead author of the study, HMRI and University of Newcastle PhD researcher Luiza Steffens-Reinhardt, said this work could lead to more effective chemotherapy for people with breast cancer.

We looked at this particular variant of a protein called p53 because our previous studies have shown that it is present at high levels in breast cancer and is associated with cancer recurrence.


We were surprised to see that by increasing the levels of this variant of p53, the breast cancer cells became unresponsive to existing therapies. Thus, inhibiting this variant could enhance people’s responses to currently used cancer treatments. We recently confirmed these findings in living subjects.”


Luiza Steffens-Reinhardt, HMRI and University of Newcastle PhD researcher, lead author of the study

Breast cancer affects more than 19,000 women every year in Australia and around one-quarter of these people develop treatment resistance.

“The primary reason women die from breast cancer is treatment resistance,” said Ms Steffens-Reinhardt.

“A breast cancer that is resistant to treatment is impossible to cure. Therefore, there is an urgent need to improve therapies that target the cells responsible for resisting these therapies.”

Associate Professor Kelly Avery-Kiejda, who supervises Steffens-Reinhardt on her research, says, this research could be a first step in better targeting breast cancer treatment.

“One in eight women in Australia develop breast cancer and while there is a 92 per cent survival rate, this doesn’t take into account secondary cancers or metastasis, which are essentially incurable,” said Associate Professor Avery-Kiejda.

“If we can identify biomarkers that predict how well a patient will respond to certain therapies, we can then target the available therapies more effectively.”

The findings were published in a paper titled ‘Alterations in the p53 isoform ratio govern breast cancer cell fate in response to DNA damage’ in the Cell Death & Disease journal. Read the full paper here: https://rdcu.be/cYrkS

This paper is the culmination of investigative work that Associate Professor Avery-Kiejda started in 2009.

This research builds on foundation research that was conducted with the generous support of the Cancer Institute NSW and the Estate of the late Joy Heather Granger.

HMRI is a partnership between the University of Newcastle, Hunter New England Health and the community.

Source:

Hunter Medical Research Institute

Journal reference:

Reinhardt, L.S., et al. (2022) Alterations in the p53 isoform ratio govern breast cancer cell fate in response to DNA damage. Cell Death and Disease. doi.org/10.1038/s41419-022-05349-9.

READ ALSO

Lab-made antibodies may be able to cure people infected with yellow fever

Consumption of dried fruits associated with higher-quality diets

Tags: Breast CancerCancerCellCell DeathChemotherapyDNADNA DamageProteinResearch

Related Posts

Lab-made antibodies may be able to cure people infected with yellow fever
Health

Lab-made antibodies may be able to cure people infected with yellow fever

March 29, 2023
Consumption of dried fruits associated with higher-quality diets
Health

Consumption of dried fruits associated with higher-quality diets

March 29, 2023
Maternal weight gain in pregnancy linked to children's risk of neurodevelopmental disorders
Health

Maternal weight gain in pregnancy linked to children's risk of neurodevelopmental disorders

March 29, 2023
Next-generation influenza vaccines show greater impact and cost-effectiveness, study suggests
Health

Next-generation influenza vaccines show greater impact and cost-effectiveness, study suggests

March 29, 2023
New evidence: Fibromyalgia could worsen opioid use disorder
Health

New evidence: Fibromyalgia could worsen opioid use disorder

March 28, 2023
What is the effect of prior BCG vaccination on the immunogenicity and efficacy of subsequent COVID-19 vaccination?
Health

What is the effect of prior BCG vaccination on the immunogenicity and efficacy of subsequent COVID-19 vaccination?

March 28, 2023
Next Post
55 insurance terms you should know about

55 insurance terms you should know about

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

POPULAR NEWS

Roblox Is Unbreakable Trello Is this safe?

Roblox Is Unbreakable Trello Is this safe?

November 4, 2022
Discord Registered Games  Discord Registered Gaming You need to join the Club

Discord Registered Games Discord Registered Gaming You need to join the Club

November 4, 2022
How To Chose the Right Data Analytics Program

How To Chose the Right Data Analytics Program

November 4, 2022
Chandrashekhar Guruji Wiki, Age, Girlfriend, Wife, Family, Biography & More

Chandrashekhar Guruji Wiki, Age, Girlfriend, Wife, Family, Biography & More

November 4, 2022
Heavy explosion on market square in Halle – three injured

Heavy explosion on market square in Halle – three injured

November 4, 2022

EDITOR'S PICK

BSI President Arne Schönbohm released

October 18, 2022

Hurricane season: Protecting beachfront properties

September 27, 2022

Sunken boat claim covered after fault undetected

July 7, 2022

UK house prices down – is this the start of the market slowdown?

August 15, 2022

About

Sepoy.net is a perfect place for people who want daily updates on news related to business, technology, entertainment, health, cryptocurrency etc.

Contact: [email protected]

Major Categories

News

Business

Tech

Economy

 

Recent Posts

  • Lab-made antibodies may be able to cure people infected with yellow fever
  • Degrowth movement: do we have to shrink the economy for the climate?
  • More ways IFRS 17 can make for wonky reporting

Pages

  • About Us
  • Contact Us
  • Disclaimer
  • DMCA
  • Home
  • Privacy Policy

© 2023 Sepoy.net

No Result
View All Result
  • Home
  • Business
  • News
  • Health
  • Tech
  • Science
  • Lifestyle
  • Travel

© 2023 Sepoy.net