SEPOY.net
No Result
View All Result
Tuesday, July 8, 2025
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
No Result
View All Result
SEPOY.NET
No Result
View All Result
Home Health

New vaccine approach can help jumpstart immune response to COVID-19

Nicholas by Nicholas
October 28, 2022
in Health
0

A Yale-designed nasal vaccine can help bolster immune responses to COVID-19 in previously vaccinated animals and reduce viral transmission, Yale researchers report Oct. 27 in the journal Science.

READ ALSO

Artificial intelligence tracks aging and damaged cells through high resolution imaging

AI chatbots are not safe replacements for therapists, research says

The new vaccine approach developed by Yale researchers -; which is known as “Prime and Spike” -; is designed to jumpstart immune response in the respiratory system, which is the first part of the body to be infected by the virus.

Intramuscular vaccine shots, which are what most people have received to protect against COVID-19 infection, provide a broad-based immune response throughout the body and help avert serious illness. However, that protection has tended to wane after about four months, leaving people susceptible to breakthrough infections and emerging variants.

The new “prime” and “spike” approach may help prevent breakthrough infections of vaccinated individuals by bolstering immune response within the mucosal lining of the respiratory tract, which are the first cells attacked by COVID-19. (“Prime” refers to the process of injecting the vaccine directly into the muscle, as is typically done. “Spike” refers to a follow-up vaccination with spike proteins, known to derive from the coronavirus, directly into the nostril, where the virus is known to enter the body.)

The nasal vaccine promotes the development of immunity within the respiratory system, which can respond more quickly to infection. By creating mucosal immunity, the vaccine helps stop the virus at its entry point, rather than waiting until later to fight back.”


Dr. Benjamin Goldman-Israelow, assistant professor of medicine (infectious diseases) at the Yale School of Medicine and co-corresponding author of the paper

The Yale team, led by Goldman-Israelow and Tianyang Mao, a graduate student in the lab of fellow co-corresponding author Akiko Iwasaki, Sterling Professor of Immunobiology, delivered the nasal vaccine to both vaccinated and unvaccinated mice. They found increased immune system response in the respiratory tracks of vaccinated mice only. Mice that had not been previously vaccinated, and vaccinated mice that did not receive nasal vaccine, died from infection. Meanwhile, mice that received the intranasal spike booster were completely protected from death and disease.

In hamsters that received the nasal vaccine, the Yale team found decreased duration and total amount of viral shedding, which is when an infected individual releases copies of the virus including through sneezing or coughing. Hamsters vaccinated with the prime and spike method were also found to have reduced viral loads when housed in the same cage with infected, unvaccinated hamsters, suggesting that the strategy reduces trains of transmission.

Researchers also found increased breadth of immune response among animals that received the nasal vaccine, indicating that the approach would be effective against a broad spectrum of coronaviruses with pandemic potential.

Goldman-Israelow noted that the Yale approach does not use live viruses, viral vectors, or adjuvants, which may make the vaccine safer.

Source

Tags: covid-19Immune ResponseimmunityMedicineOCTRespiratoryVaccineVirus

Related Posts

Artificial intelligence tracks aging and damaged cells through high resolution imaging
Health

Artificial intelligence tracks aging and damaged cells through high resolution imaging

July 8, 2025
AI chatbots are not safe replacements for therapists, research says
Health

AI chatbots are not safe replacements for therapists, research says

July 8, 2025
Aspartame triggers genetic changes tied to glioblastoma severity
Health

Aspartame triggers genetic changes tied to glioblastoma severity

July 8, 2025
Global experts release first guide to protect patients undergoing innovative surgery
Health

Global experts release first guide to protect patients undergoing innovative surgery

July 8, 2025
Astrocytes influence metabolism and cognitive function in obesity
Health

Astrocytes influence metabolism and cognitive function in obesity

July 7, 2025
Cysteine plays key role in weight loss and fat metabolism
Health

Cysteine plays key role in weight loss and fat metabolism

July 7, 2025
Next Post

CSU party conference: Söder puts pressure on the traffic light

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

About

Sepoy.net is a perfect place for people who want daily updates on news related to business, technology, entertainment, health, cryptocurrency etc.

Contact: hello@sepoy.net

Major Categories

News

Business

Tech

Economy

 

Recent Posts

  • DIM paras kasinopeli Leovegas -panospalkinto -aseman arvostelu innokkaasti saada mehukkaita voittoja?
  • 21 Kasino Nachprüfung, Exclusive 50 Spins No Abschlagzahlung Provision
  • Cleopatra Slot Comment: Jack Hammer 2 slot a real, high paying antique!

Pages

  • About Us
  • Contact Us
  • Disclaimer
  • DMCA
  • Home
  • Privacy Policy

© 2023 Sepoy.net

No Result
View All Result
  • Home
  • Business
  • News
  • Health
  • Tech
  • Science
  • Lifestyle
  • Travel

© 2023 Sepoy.net