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Owlstone Medical secures investment from Cystic Fibrosis Foundation

Nicholas by Nicholas
March 29, 2025
in Health
0
Owlstone Medical secures investment from Cystic Fibrosis Foundation

Owlstone Medical (“Owlstone”), the global leader in Breath Biopsy® for applications in early disease detection and precision medicine, today announced that the Cystic Fibrosis Foundation has made an up to USD $2.3 million equity investment (circa £1.7 million) in Owlstone to develop a breath test for Pseudomonas aeruginosa (PA) detection in patients with cystic fibrosis (CF).

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Billy Boyle, co-founder and CEO at Owlstone Medical. Image Credit: Owlstone Medical

The goal of the investment is to develop a breath-based test suitable for both early detection of new PA infection and monitoring of chronic infection in patients with CF, with diagnostic accuracy at least comparable to sputum culture tests. Leveraging Owlstone’s expertise in volatile organic compound (VOC) analysis, the test will also be developed to distinguish PA from S. aureus and other common respiratory bacterial pathogens found in the lungs of people with CF.

Initial work will focus on chronic PA to establish scientific proof-of-principle that VOCs on breath can identify this lung infection and be utilized as part of long-term monitoring of infection. If successful, additional work can be organized to test the ability of this approach to detect new PA infections—an important event in the clinical care of people with CF.

CF is a progressive genetic disorder affecting over 105,000 individuals worldwide. Characterized by excessive mucus production that traps pathogens in the lungs, CF causes severe lung infections and can lead to respiratory failure. PA, which affects an estimated 25% of CF patients, represents a significant threat to people with CF. Once established in the lungs, PA is very difficult to eliminate, making early detection and aggressive treatment of infection critical.

PA is typically detected through sputum culture; however, this is difficult to perform in many children and is becoming increasingly challenging in adults with CF because of the beneficial effects of other therapies that reduce airway mucus and hence the ability to provide a suitable sputum sample.

Owlstone’s experience in the breath-based detection of infectious disease through projects with the U.S. Department of Defense, the Gates Foundation, and other partners, underpinned by our proprietary Breath Biopsy platform, places Owlstone in an excellent position to help improve outcomes for CF patients infected with Pseudomonas aeruginosa.” 

Billy Boyle, co-founder and CEO, Owlstone Medical

He added: “Data from the study will also be entered into Owlstone’s Breath VOC Atlas, where it will continue to be used in clinical studies and analyses to support further biomarker and test development across a wide range of disease areas.” 

Tags: BacteriaBacterialBiomarkerBiopsyCancerChildrenChronicCompoundCystic FibrosisDiagnosticFibrosisGeneticLiverLiver DiseaseLung CancerLungsMedicinePrecision MedicineResearchRespiratory

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