Sepoy-logo
No Result
View All Result
Thursday, November 30, 2023
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
No Result
View All Result
SEPOY.NET
No Result
View All Result
Home Health

Scientists identify immune targets for chemotherapy-resistant breast cancers

Nicholas by Nicholas
September 26, 2022
in Health
0

Scientists have identified immune cell types that could be targeted to develop specific immunotherapies in chemotherapy-resistant breast cancers.

Researchers from King’s College London and The Institute of Cancer Research, London, with support from Breast Cancer Now, have performed a deep dive into the different immune markers within tumor tissues and blood samples of early breast cancer patients whose cancer failed to respond to chemotherapy given to them prior to surgery.

The research, published today in Clinical Cancer Research, a journal of the American Association for Cancer Research, gives insight into the function of immune cells in patients with chemotherapy-resistant breast cancers. While chemotherapy may not kill cancer cells in these high-risk patients, immunotherapy, a type of treatment that helps the immune system to attack cancer cells, may provide a benefit.

To investigate the immune environment that surrounds these chemotherapy-resistant tumors, researchers employed multiple and novel complementary technologies looking at proteins and genes on both pre-treatment and post-treatment breast cancer tissue. They also measured how 1,330 cancer and immune-related genes within cancer tissues were affected by chemotherapy.

They found that chemotherapy-resistant cancer cells had very few immune cells around them, but chemotherapy did induce changes in several immune cell types. Specifically, they found increases in the number of “innate” (first responder) cells such as neutrophils and natural killer (NK) cells. NK cells help the body to fight infection and cancer. But analysis found the increased NK cells in patients with chemotherapy-resistant disease lacked cytotoxic activity – the ‘killing instinct’.

Researchers also found immune-related genes associated with NK cells were those associated with cell inhibition or exhaustion, which meant NK cells were unable to fight cancer cells. This new insight into the behavior of NK cells could be used to develop specific immunotherapies for these high-risk patients. This would need to be investigated in future clinical trials.

These findings also show that blood monitoring during chemotherapy may help predict chemotherapy response early, potentially allow for tailoring of treatment prior to surgery.

Chemotherapy resistance in aggressive early breast cancers is a major reason why cancer regrows after treatment, contributing significantly to people not surviving their disease. In order to find the right targets for drug developments, it’s important to have a deep understanding of the complex mechanisms that allow some cancer cells to resist treatment, then hide from our immune system to only re-emerge later when they’re harder to eradicate.


Our work has identified several cell types that would be worth investigating further to understand how they are interacting with the resistant cancer cell and how we can tweak that for our benefit. I am excited to continue to investigate these findings further.”


Dr Sheeba Irshad, Lead Author, Cancer Research UK Clinician Scientist, King’s College London

Professor Andrew Tutt, Director of the Breast Cancer Now Toby Robins Research Centre at The Institute of Cancer Research, London, and of the Breast Cancer Now Research Unit at King’s College London, said: “Great strides have been made in harnessing immunotherapies to treat several types of cancer, but we need to do better to realize their potential for patients with breast cancer.

“This exciting work advances our understanding of the interaction between cancer cells and the immune system during treatment, and why existing treatments work well for some patients, but not others. I hope this research will help us to enhance the anti-cancer immune response in breast cancer, particularly for patients whose cancer has not responded well to chemotherapy.”

Dr Kotryna Temcinaite, Senior Research Communications Manager at Breast Cancer Now, said: “With an estimated 35,000 people living with incurable secondary (metastatic) breast cancer in the UK, it’s vital we develop smarter, more effective treatments to ensure fewer people hear the devastating news the disease has returned and spread to other parts of the body. This exciting early-stage research, which has been part-funded by Breast Cancer Now, helps to lay the groundwork for discovering a way to target breast cancer cells that resist chemotherapy treatment. We hope by building on these findings, scientists will ultimately be able to develop immunotherapy treatments that may help more people survive breast cancer.”

Source:

Journal reference:

Gazinska, P., et al. (2022) Dynamic Changes in the NK-, Neutrophil-, and B-cell Immunophenotypes Relevant in High Metastatic Risk Post Neoadjuvant Chemotherapy–Resistant Early Breast Cancers. Clinical Cancer Research. doi.org/10.1158/1078-0432.CCR-22-0543.

Source

READ ALSO

The effects of vitamin K on bone health

Study sheds new light on the profound influence of music on our moral compass

Tags: BloodBreast CancerCancerCellChemotherapyGenesImmune SystemImmunotherapyResearchSurgery

Related Posts

The effects of vitamin K on bone health
Health

The effects of vitamin K on bone health

November 30, 2023
Study sheds new light on the profound influence of music on our moral compass
Health

Study sheds new light on the profound influence of music on our moral compass

November 30, 2023
Lyme disease aftercare: new insights into persistent symptoms
Health

Lyme disease aftercare: new insights into persistent symptoms

November 29, 2023
PlaqueTec recruits first ten patients in BIOPATTERN trial
Health

PlaqueTec recruits first ten patients in BIOPATTERN trial

November 29, 2023
Researchers introduce CRISPR-mediated genome and cancer shredding as a conceptual paradigm to treat recurrent gliomas
Health

Researchers introduce CRISPR-mediated genome and cancer shredding as a conceptual paradigm to treat recurrent gliomas

November 29, 2023
Government launches consultation to introduce new protections for children from future strike action
Health

Government launches consultation to introduce new protections for children from future strike action

November 29, 2023
Next Post

Comment on Meloni's victory in Italy: respect for an election

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

POPULAR NEWS

Roblox Is Unbreakable Trello Is this safe?

Roblox Is Unbreakable Trello Is this safe?

November 4, 2022
Discord Registered Games  Discord Registered Gaming You need to join the Club

Discord Registered Games Discord Registered Gaming You need to join the Club

November 4, 2022
How To Chose the Right Data Analytics Program

How To Chose the Right Data Analytics Program

November 4, 2022
Heavy explosion on market square in Halle – three injured

Heavy explosion on market square in Halle – three injured

November 4, 2022

Shivon Zilis Wiki, Height, Age, Boyfriend, Husband, Family, Biography & More

July 11, 2022

EDITOR'S PICK

Mortality risk higher among children with primary immunodeficiency diseases infected with SARS-CoV-2

September 16, 2022

Ex-NBA player pleads guilty in health insurance fraud case

August 29, 2022
How to start and run an insurance brokerage firm

How to start and run an insurance brokerage firm

November 28, 2022
Ukraine: Selenskyj calls for special tribunal for Russians

Ukraine: Selenskyj calls for special tribunal for Russians

November 30, 2022

About

Sepoy.net is a perfect place for people who want daily updates on news related to business, technology, entertainment, health, cryptocurrency etc.

Contact: [email protected]

Major Categories

News

Business

Tech

Economy

 

Recent Posts

  • Terra Classic : l’USTC explose de +300% – Que se passe-t-il ?
  • The effects of vitamin K on bone health
  • Liveblog zum Krieg in Nahost: Mindestens eine Frau bei Anschlag in Jerusalem getötet

Pages

  • About Us
  • Contact Us
  • Disclaimer
  • DMCA
  • Home
  • Privacy Policy

© 2023 Sepoy.net

No Result
View All Result
  • Home
  • Business
  • News
  • Health
  • Tech
  • Science
  • Lifestyle
  • Travel

© 2023 Sepoy.net

x