SEPOY.net
No Result
View All Result
Monday, July 7, 2025
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
No Result
View All Result
SEPOY.NET
No Result
View All Result
Home Health

Significance of mathematical modeling in understanding complex biological processes

Nicholas by Nicholas
February 25, 2023
in Health
0
Significance of mathematical modeling in understanding complex biological processes

Humans and animals detect different stimuli such as light, sound, and odor through nerve cells, which then transmit the information to the brain. Nerve cells must be able to adjust to the wide range of stimuli they receive, which can range from very weak to very strong. To do this, they may become more or less sensitive to stimuli (sensitization and habituation), or they may become more sensitive to weaker stimuli and less sensitive to stronger stimuli for better overall responsiveness (gain control). However, the exact way this happens is not yet understood.

READ ALSO

Cysteine plays key role in weight loss and fat metabolism

Reversing immune fatigue offers new hope for cancer treatment

To better understand the process of gain control, a research team led by Professor Kimura at Nagoya City University in Japan studied the roundworm C. elegans. They found that, when the worm first smells an unpleasant odor, its nerve cells exhibit a large, quickly increasing, and continuous response to both weak and strong stimuli. However, after exposure to the odor, the response is smaller and slower to weak stimuli but remains large to strong stimuli, similar to the response to the first exposure to the odor. Because the experience of odor exposure causes more efficient movement of worms away from the odor, the nerve cells have changed their response to better adapt to the stimulus using gain control.

Then the researchers used mathematical modeling to understand this process. Mathematical modeling is a powerful tool that can be used to better understand complex biological processes. They found that the “response to first smell” consists of fast and slow components, while the “response after exposure” only consists of the slow component, meaning that the odor experience inhibits the fast component to achieve gain control. They further found that both responses could be described by a simple differential equation and that the slow and fast components correspond to the leaky integration of a first and second derivative term of the odor concentration that the worm senses, respectively. The results of this study showed that the prior odor experience only appears to inhibit the mechanism required for the fast component.

Based on these results, the research team further assumed that the different responses of nerve cells for gain control can be regulated by a relatively simple process involving genes. They then indeed found a set of genes (regulator of G protein and protein kinase G) that are required for the process.

The results of this study represent an insightful use of mathematical modeling to elucidate the basis of nerve cell activity and demonstrate the potential for broadening our understanding of life phenomena by combining mathematical models with various biological experiments.

The modeling result was totally surprising. Because multiple aspects of the nerve cell responses are different, we expected more complicated processes would be involved. The simple model encouraged us to find key genes that change all aspects of the difference, and we think we did it.”


Koutarou D. Kimura, Professor, Nagoya City University

In conclusion, this research highlights the importance of mathematical modeling in better understanding complex biological processes. By combining mathematical models with biological experiments, researchers can gain new insights into the way that cells and organisms function and propose new experiments, which may not be possible without modeling. This can ultimately lead to new breakthroughs in the fields of biology and medicine.

Source:

Journal reference:

Ikejiri, Y., et al. (2023) Neural mechanism of experience-dependent sensory gain control in C. elegans. Neuroscience Research. doi.org/10.1016/j.neures.2023.01.006.

Tags: BrainCellGenesNerveProteinResearch

Related Posts

Cysteine plays key role in weight loss and fat metabolism
Health

Cysteine plays key role in weight loss and fat metabolism

July 7, 2025
Reversing immune fatigue offers new hope for cancer treatment
Health

Reversing immune fatigue offers new hope for cancer treatment

July 7, 2025
Flavonoid diversity, not just quantity, drives better health outcomes
Health

Flavonoid diversity, not just quantity, drives better health outcomes

July 7, 2025
Preeclampsia in pregnancy reduces risk of some cancers but raises endometrial cancer odds
Health

Preeclampsia in pregnancy reduces risk of some cancers but raises endometrial cancer odds

July 7, 2025
Ireland's first and only BioBrillouin microscope installed at Trinity College Dublin
Health

Ireland's first and only BioBrillouin microscope installed at Trinity College Dublin

July 5, 2025
Planned C-sections linked to increased risk of developing childhood leukemia
Health

Planned C-sections linked to increased risk of developing childhood leukemia

July 4, 2025
Next Post
Cedars-Sinai addresses life-threatening aorta condition

Cedars-Sinai addresses life-threatening aorta condition

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

About

Sepoy.net is a perfect place for people who want daily updates on news related to business, technology, entertainment, health, cryptocurrency etc.

Contact: hello@sepoy.net

Major Categories

News

Business

Tech

Economy

 

Recent Posts

  • Cash Relationship snap this site Dolphin’s Pearl Trial because of the Greentube Play all of our Totally free Ports
  • Monkey Currency Harbors Play for Online BetSoft Video game
  • Greatest On-line poker Web sites the real deal Currency 2025 Play Internet poker

Pages

  • About Us
  • Contact Us
  • Disclaimer
  • DMCA
  • Home
  • Privacy Policy

© 2023 Sepoy.net

No Result
View All Result
  • Home
  • Business
  • News
  • Health
  • Tech
  • Science
  • Lifestyle
  • Travel

© 2023 Sepoy.net