ASTN2 gene knockout in mice reveals key autism-related behaviors
More than 70 genes have been linked to autism spectrum disorder (ASD), a developmental condition in which differences in the ...
Tag: Knockout
CD5 knockout using CRISPR boosts CAR T cell therapy efficacy
The effectiveness of CAR T cell therapy against a variety of cancers, including solid tumors, could be boosted greatly by ...
Neuropathic pain study uncovers pathophysiological mechanism and promising therapeutic target
Neuropathic pain -; abnormal hypersensitivity to stimuli -; is associated with impaired quality of life and is often poorly managed. ...
New study aims to elucidate the role of p21 in chronic lung inflammation
A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" ...
An emerging target for chronic kidney disease treatment – DNA-PKcs
Around 10% of the global population is affected by chronic kidney disease (CKD). The risk of CKD progressing into end-stage ...
Study reveals the mechanism through which Sirtuin 7 protein suppresses thermogenesis in mice
Mammals convert the energy stored in adipose (fat) tissue into heat via a process known as thermogenesis. This process is ...
Researchers uncover the host protease CAPN2 as a novel host factor that aids the infection of SARS-CoV-2
In a recent study posted to the bioRxiv* preprint server, researchers investigated the potential of the calpain-2 (CAPN2) molecule as ...
Rational treatment strategies for SARS-CoV-2 derived from human pluripotent stem cells models
In a recent study posted to the bioRxiv* preprint server, researchers in Australia explored the molecular mechanisms of the pulmonary ...
Cancer cells produce small amount of collagen that impacts tumor microbiome and immunity
Cancer cells produce small amounts of their own form of collagen, creating a unique extracellular matrix that affects the tumor ...
