Tim-3 identified as promising therapeutic target for Alzheimer's disease
Tim-3 is an immune checkpoint molecule involved in immunity and inflammation recently linked to late-onset Alzheimer's disease (AD), but its ...
Tag: Mouse Model
Triple therapy reduces tumor burden and improves survival in glioblastoma models
A new research paper was published in Oncotarget, Volume 16, on March 27, 2025, titled "Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy ...
Semi-synthetic bile acid could be a promising therapeutic option for TH17-mediated intestinal diseases
A research team from the Medical University of Vienna has made further progress in the treatment of intestinal inflammation. A ...
Gene therapy breakthrough offers hope for severe Dravet syndrome cases
Researchers successfully use an adeno-associated viral vector to restore brain function in a mouse model of SCN1B-linked DEE52, reducing seizures ...
Opioid δ-receptor agonists show promise for treating IBS-like symptoms
New research suggests that δ-receptor agonists regulate intestinal motility and relieve abdominal pain in a mouse model of irritable bowel ...
Research unveils synergistic effects of tau and beta-amyloid in Alzheimer's
A research team from the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) has discovered that the two ...
Mapping cerebellar nuclei outputs in an autism mouse model
The cerebellum plays a critical role in both motor and non-motor functions, and its dysfunction is linked to various mental ...
Setd2 catalytic activity is crucial for embryonic development in mice
A recent study delves into the pivotal role of Setd2, a histone methyltransferase enzyme, in embryonic development within mice. Setd2 ...
New insights into the developmental trajectory of social behaviors in fragile X syndrome
In a comprehensive Genomic Press Interview, researchers from the University of Texas Health Science Center at San Antonio and Hirosaki ...
Aging reduces cancer risk by limiting cell regeneration
When it comes to cancer, aging is a double-edged sword, researchers are increasingly learning. Age is considered the most important risk ...