WEHI team makes major strides in the fight against Parkinson's disease
WEHI researchers have made a huge leap forward in the fight against Parkinson's disease, solving a decades-long mystery that paves ...
Tag: Ubiquitin
Ubiquitination plays a key role in cancer stem cell function and treatment resistance
This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), shedding light on ...
Study unravels the complex interplay of the UPS in cancer development and treatment
A new review published in Genes & Diseases explores the pivotal role of the ubiquitin-proteasome system (UPS) in regulating the ...
Evaluating biomarkers for diagnosing minimal hepatic encephalopathy in cirrhotic patients
Background and aims The performance of neurodegenerative biomarkers-neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), tau, and ubiquitin carboxy-terminal ...
New insights on protein degraders open doors to treatment for 'undruggable' diseases
Researchers at the University of Dundee have revealed in the greatest detail yet the workings of molecules called 'protein degraders' ...
ACBI3 molecule offers new hope for targeting KRAS mutations in cancer
KRAS is the most mutated gene in cancer with mutations occurring in 17%–25% of all cancers, affecting millions of patients ...
New research center delves into ubiquitin's role in cancer
The German Research Foundation (DFG) has now approved a new Collaborative Research Centre in the search for innovative therapies against ...
ZIP7: A novel target for treating degenerative diseases associated with misfolded proteins
Proteins are the workhorses of life. Organisms use them as building blocks, receptors, processors, couriers and catalysts. A protein's structure ...
Study uncovers critical roles for USP1 in Ewing sarcoma
A new research paper was published in Genes & Cancer on February 5, 2024, entitled, "Roles of USP1 in Ewing ...
Unlocking ACE2: The enzyme that links COVID-19, heart disease, and diabetes
Within the renin-angiotensin system (RAS), which regulates blood volume, electrolyte balance, and systemic vascular resistance within the body, the angiotensin-converting ...