SEPOY.net
No Result
View All Result
Monday, June 16, 2025
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
No Result
View All Result
SEPOY.NET
No Result
View All Result
Home Health

Anti-inflammatory pain relievers may worsen inflammation in osteoarthritis

Nicholas by Nicholas
November 21, 2022
in Health
0
Anti-inflammatory pain relievers may worsen inflammation in osteoarthritis

Taking anti-inflammatory pain relievers like ibuprofen and naproxen for osteoarthritis may worsen inflammation in the knee joint over time, according to a new study being presented next week at the annual meeting of the Radiological Society of North America (RSNA).

READ ALSO

Rapid generation of functional blood vessels from human stem cells

Cardiovascular deaths surge among less educated Americans

Osteoarthritis is the most common form of arthritis, affecting more than 32 million adults in the U.S. and more than 500 million people worldwide. It occurs most frequently in the hands, hips and knees. In people with osteoarthritis, the cartilage that cushions the joint gradually wears away. Arthritis is often accompanied by inflammation, or swelling, of the joint, which can be painful.

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed for osteoarthritis pain and inflammation. But little is known of the long-term effects of these drugs on disease progression.

To date, no curative therapy has been approved to cure or reduce the progression of knee osteoarthritis. NSAIDs are frequently used to treat pain, but it is still an open discussion of how NSAID use influences outcomes for osteoarthritis patients. In particular, the impact of NSAIDs on synovitis, or the inflammation of the membrane lining the joint, has never been analyzed using MRI-based structural biomarkers.”


Johanna Luitjens, study’s lead author, postdoctoral scholar, Department of Radiology and Biomedical Imaging, University of California, San Francisco

Dr. Luitjens and colleagues set out to analyze the association between NSAID use and synovitis in patients with osteoarthritis of the knee and to assess how treatment with NSAIDs affects joint structure over time.

“Synovitis mediates development and progression of osteoarthritis and may be a therapeutic target,” Dr. Luitjens said. “Therefore, the goal of our study was to analyze whether NSAID treatment influences the development or progression of synovitis and to investigate whether cartilage imaging biomarkers, which reflect changes in osteoarthritis, are impacted by NSAID treatment.”

For the study, 277 participants from the Osteoarthritis Initiative cohort with moderate to severe osteoarthritis and sustained NSAID treatment for at least one year between baseline and four-year follow-up were included in the study and compared with a group of 793 control participants who were not treated with NSAIDs. All participants underwent 3T MRI of the knee initially and after four years. Images were scored for biomarkers of inflammation.

Cartilage thickness, composition and other MRI measurements served as noninvasive biomarkers for evaluating arthritis progression.

The results showed no long-term benefit of NSAID use. Joint inflammation and cartilage quality were worse at baseline in the participants taking NSAIDs, compared to the control group, and worsened at four-year follow-up.

“In this large group of participants, we were able to show that there were no protective mechanisms from NSAIDs in reducing inflammation or slowing down progression of osteoarthritis of the knee joint,” Dr. Luitjens said. “The use of NSAIDs for their anti-inflammatory function has been frequently propagated in patients with osteoarthritis in recent years and should be revisited, since a positive impact on joint inflammation could not be demonstrated.”

According to Dr. Luitjens, there are several possible reasons why NSAID use increases synovitis.

“On the one hand, the anti-inflammatory effect that normally comes from NSAIDs may not effectively prevent synovitis, with progressive degenerative change resulting in worsening of synovitis over time,” she said. “On the other hand, patients who have synovitis and are taking pain-relieving medications may be physically more active due to pain relief, which could potentially lead to worsening of synovitis, although we adjusted for physical activity in our model.”

Dr. Luitjens noted that prospective, randomized studies should be performed in the future to provide conclusive evidence of the anti-inflammatory impact of NSAIDs.

Co-authors are Charles McCulloch, Ph.D., Thomas Link, M.D., Ph.D., Felix Gassert, M.D., Gabby Joseph, Ph.D., and John Lynch, Ph.D.

Source:

Radiological Society of North America

Tags: Anti-InflammatoryArthritisCartilageDrugsibuprofenImagingInflammationJoint InflammationKneekneecapOsteoarthritisPainpHSynovitis

Related Posts

Rapid generation of functional blood vessels from human stem cells
Health

Rapid generation of functional blood vessels from human stem cells

June 14, 2025
Cardiovascular deaths surge among less educated Americans
Health

Cardiovascular deaths surge among less educated Americans

June 14, 2025
Small antibodies provide broad protection against SARS coronaviruses
Health

Small antibodies provide broad protection against SARS coronaviruses

June 14, 2025
c-Fos exhibits a dual role in memory formation and Alzheimer's disease
Health

c-Fos exhibits a dual role in memory formation and Alzheimer's disease

June 14, 2025
BRCA mutations sharply increase risk of implant-associated lymphoma
Health

BRCA mutations sharply increase risk of implant-associated lymphoma

June 14, 2025
Study reveals sharp increase in global incidents of healthcare-related harm
Health

Study reveals sharp increase in global incidents of healthcare-related harm

June 14, 2025
Next Post
Holiday shopping cyber risks: Tips to share with clients

Holiday shopping cyber risks: Tips to share with clients

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

About

Sepoy.net is a perfect place for people who want daily updates on news related to business, technology, entertainment, health, cryptocurrency etc.

Contact: hello@sepoy.net

Major Categories

News

Business

Tech

Economy

 

Recent Posts

  • RTP bei Spielbank Cleopatra Slot für echtes Geld Slots Weswegen Zocker diese RTP drauf haben sollten
  • Alive Dealer Baccarat How and you may Where to Enjoy On the web
  • Thunderkick Remark: Gamble Totally free Slots From casino 1 percent bonus Thunderkick

Pages

  • About Us
  • Contact Us
  • Disclaimer
  • DMCA
  • Home
  • Privacy Policy

© 2023 Sepoy.net

No Result
View All Result
  • Home
  • Business
  • News
  • Health
  • Tech
  • Science
  • Lifestyle
  • Travel

© 2023 Sepoy.net