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WEDNESDAY, Might 25, 2022

COVID-19 could make a comeback after an contaminated particular person has gone via a spherical of Paxlovid, the antiviral used to attenuate a bout with the coronavirus, in keeping with an advisory issued Tuesday by the U.S. Facilities for Illness Management and Prevention.

“Current case studies doc that some sufferers with regular immune response who’ve accomplished a five-day course of Paxlovid for laboratory-confirmed an infection and have recovered can expertise recurrent sickness two to eight days later, together with sufferers who’ve been vaccinated and/or boosted,” the CDC advisory stated.

In these circumstances of “COVID-19 rebound,” the sickness improved or resolved inside a median three days, with out extra anti-COVID remedy, the CDC stated.

A relapse after Paxlovid remedy doesn’t suggest the antiviral does not work, the advisory added.

“A quick return of signs could also be a part of the pure historical past of SARS-CoV-2 (the virus that causes COVID-19) an infection in some individuals, unbiased of remedy with Paxlovid and no matter vaccination standing,” the CDC stated.

The company added that “Paxlovid continues to be beneficial for early-stage remedy of gentle to average COVID-19 amongst individuals at excessive danger for development to extreme illness.”

In medical trials for Paxlovid, such a rebound was seen amongst some individuals who had been within the placebo group and did not get the drug, famous Dr. Amesh Adalja, a senior scholar on the Johns Hopkins Heart for Well being Safety, in Baltimore.

Within the unique research, virus ranges rose after 10 days in 1% to 2% of these taking both the drug or placebo tablets, Pfizer and the U.S. Meals and Drug Administration have famous.

“It is unclear how frequent the phenomenon of COVID-19 rebound is, whether or not it’s a pure development of the sickness in sure people, what this relationship with Paxlovid is, and what’s behind it,” Adalja stated.

He added that individuals with rebound COVID “haven’t had extreme sickness,” however ought to isolate to guard others.

“Individuals ought to be alert to a rebound in signs and check themselves and assume contagiousness if optimistic,” Adalja stated.

Extra data

The U.S. Facilities for Illness Management and Prevention has extra about COVID-19.

SOURCES: U.S. Facilities for Illness Management and Prevention, assertion, Might 24, 2022; Amesh Adalja, MD, senior scholar, Johns Hopkins Heart for Well being Safety, Baltimore

By Dennis Thompson HealthDay Reporter