Sepoy-logo
No Result
View All Result
Saturday, January 28, 2023
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
No Result
View All Result
SEPOY.NET
No Result
View All Result
Home Health

Huge multi-omic data analysis deciphers colorectal cancer genetics

Nicholas by Nicholas
December 21, 2022
in Health
0
Huge multi-omic data analysis deciphers colorectal cancer genetics

An analysis of more than 100,000 colorectal cancer cases and 154,000 healthy controls published in Nature Genetics uncovered hundreds of signals that may serve as new treatment and prevention targets.

This study is twice as large as previous genome-wide association studies, according to the paper. The collaboration included researchers affiliated with hundreds of studies and institutions across Europe, North America and Asia, including Stephanie Schmit, PhD, MPH, Vice Chair of Cleveland Clinic’s Genomic Medicine Institute. Genome-wide association studies on this scale help researchers identify genes associated with colorectal cancer and also the biological pathways affected by those genes.

“This is a major stride in understanding the complexity of genetic susceptibility to colorectal cancer,” says Dr. Schmit, who first started working on part of this effort during her PhD training about a decade ago. “The data uncovered some pathways that could hold potential for prevention and treatment of the disease, and provide continued reinforcement of exploring mechanisms outside of the colon, such as the immune system.”

Dr. Schmit was among the group sharing first authorship on this study, representing the Colorectal Transdisciplinary Study (CORECT) funded by National Institutes of Health grant U19CA148107.

Colorectal cancer develops from growths, known as polyps, in the inner lining of the colon. The disease affects more than 1.9 million people worldwide annually. Though some rare mutations passed through families are associated with very high risk of colorectal cancer, but most of the genetic variants contributing to colorectal cancer are common in the population and each confer a very small increased risk on their own. Combined with environmental and lifestyle factors and cancer screening behaviors, genetics are one important piece of puzzle for this complex disease.

Researchers compared genomic data from people with and without colorectal cancer to identify genetic associations with the disease. The study identified 250 independent risk associations, 50 of which were previously undiscovered, through analyzing genomic, transcriptomic and methylomic data. The analyses also found 155 high-confidence effector genes, which encode molecules that affect biological activity.

Understanding the “complete picture” of colorectal cancer

After identifying the genes, researchers could then examine which risk-associated genes cause changes in other tissues outside of the colonic mucosa, the tissue lining the colon where cancerous polyps develop. The results showed more than a third of effector genes most likely act outside the colonic mucosa.

The study also found that colorectal cancer risk stems from variation in normal colorectal function on a molecular level: homeostasis, proliferation, cell adhesion, migration, immunity and microbial interactions.

The findings reveal that identified genes could affect multiple systems, including cardiovascular, nervous and immune functions. Gut microbiota is also a potential interest area for future research, according to the paper.

The new analysis and continued collaboration is a “springboard” for research efforts that could translate into clinical practice, Dr. Schmit says.

These discovery efforts help confirm which avenues to explore in colorectal cancer research moving forward. The additional data on biological pathways provide information for discerning genetic risk for colorectal cancer and how these insights could potentially be leveraged for risk-stratified screening and for the development of new prevention and treatment approaches.”


Dr. Stephanie Schmit, PhD, MPH, Vice Chair of Cleveland Clinic’s Genomic Medicine Institute

Source:

Journal reference:

Fernandez-Rozadilla, C., et al. (2022) Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries. Nature Genetics. doi.org/10.1038/s41588-022-01222-9.

READ ALSO

Win 1 of 15 EVOLVE manual pipette starter packs from INTEGRA Biosciences

Latest figures on the COVID-19 pandemic collected by UCLA Health hospitals and clinics

Tags: CancerColorectalColorectal CancerGenesGeneticGeneticsGenomeGenomicMedicineResearch

Related Posts

Win 1 of 15 EVOLVE manual pipette starter packs from INTEGRA Biosciences
Health

Win 1 of 15 EVOLVE manual pipette starter packs from INTEGRA Biosciences

January 28, 2023
Latest figures on the COVID-19 pandemic collected by UCLA Health hospitals and clinics
Health

Latest figures on the COVID-19 pandemic collected by UCLA Health hospitals and clinics

January 28, 2023
Top urologists share their insights and practical tips at "Urology on the Beach"
Health

Top urologists share their insights and practical tips at "Urology on the Beach"

January 27, 2023
Protein adduction and p53 tumor suppressor inhibition
Health

Protein adduction and p53 tumor suppressor inhibition

January 27, 2023
Survey: Trust in genetics increased significantly during the pandemic
Health

Survey: Trust in genetics increased significantly during the pandemic

January 27, 2023
Benefits of telemedicine for healthcare outweigh its operating costs
Health

Benefits of telemedicine for healthcare outweigh its operating costs

January 27, 2023
Next Post
New method uses artificial DNA to target and kill cancer cells

New method uses artificial DNA to target and kill cancer cells

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

POPULAR NEWS

Roblox Is Unbreakable Trello Is this safe?

Roblox Is Unbreakable Trello Is this safe?

November 4, 2022
Discord Registered Games  Discord Registered Gaming You need to join the Club

Discord Registered Games Discord Registered Gaming You need to join the Club

November 4, 2022
How To Chose the Right Data Analytics Program

How To Chose the Right Data Analytics Program

November 4, 2022
Chandrashekhar Guruji Wiki, Age, Girlfriend, Wife, Family, Biography & More

Chandrashekhar Guruji Wiki, Age, Girlfriend, Wife, Family, Biography & More

November 4, 2022
Heavy explosion on market square in Halle – three injured

Heavy explosion on market square in Halle – three injured

November 4, 2022

EDITOR'S PICK

What are the top social tokens waiting to take off? | Find out now on The Market Report

May 10, 2022
World Cup column “Qatar mood”: The veil of oblivion?

World Cup column “Qatar mood”: The veil of oblivion?

December 3, 2022

Why You Need Antibiotics Study Guide

June 22, 2022

Olympic Games 1972: In the country of the class enemy

September 6, 2022

About

Sepoy.net is a perfect place for people who want daily updates on news related to business, technology, entertainment, health, cryptocurrency etc.

Contact: [email protected]

Major Categories

News

Business

Tech

Economy

 

Recent Posts

  • Conquer The World’s Most Challenging Trek: Tips For Trekking To K2 Base Camp!
  • Win 1 of 15 EVOLVE manual pipette starter packs from INTEGRA Biosciences
  • Deadly danger: feverish search for radioactive capsule in Australia

Pages

  • About Us
  • Contact Us
  • Disclaimer
  • DMCA
  • Home
  • Privacy Policy

© 2022 Sepoy.net

No Result
View All Result
  • Home
  • Business
  • News
  • Health
  • Tech
  • Science
  • Lifestyle
  • Travel

© 2022 Sepoy.net