SEPOY.net
No Result
View All Result
Wednesday, June 18, 2025
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
No Result
View All Result
SEPOY.NET
No Result
View All Result
Home Health

Cardiac MRI of individuals with acute or post-acute COVID-19

Nicholas by Nicholas
January 4, 2023
in Health
0
Cardiac MRI of individuals with acute or post-acute COVID-19

In a recent study published in the Journal of Clinical Ultrasound, researchers in Italy reported cardiac magnetic resonance (CMR) findings in individuals with myocarditis-like syndrome during the acute phase of SARS-CoV-2 infection (AMCovS) and post-acute phase (cPACS).

READ ALSO

Rare pancreatic cancer patients show remarkable outcomes with immunotherapy

Disrupted biological rhythms in teens can produce unexpected brain effects

Study: Cardiac magnetic resonance findings in acute and post-acute COVID-19 patients with suspected myocarditis. Image Credit: Radiological imaging / ShutterstockStudy: Cardiac magnetic resonance findings in acute and post-acute COVID-19 patients with suspected myocarditis. Image Credit: Radiological imaging / Shutterstock

Cardiovascular injury has been frequently observed among SARS-CoV-2-positive individuals since angiotensin-converting enzyme 2 (ACE2) receptors, essential for SARS-CoV-2 entry into the host, are present in the heart. Additionally, indirect coronavirus disease 2019 (COVID-19)-associated mechanisms, including cytokine excess, oxygen demand-supply mismatch, endothelial inflammation, and thrombosis, could result in myocardial inflammation, dysfunction, and ischemia. CMR imaging enables the non-invasive characterization of myocardial alterations.

About the study

In the present retrospective study, researchers reported CMR findings in AMCovS and cPACS patients.

Data were obtained from RT-PCR (reverse transcription-polymerase chain reaction)-confirmed SARS-CoV-2-infected individuals with clinically suspected myocarditis in the acute and post-acute COVID-19 phases, for whom 1.5 Tesla CMR imaging was performed between September 2020 and January 2022. Data were obtained from all patients’ electronic health records, including anthropometric variables, laboratory analysis data, cardiac comorbid conditions, and during SARS-CoV-2 infection for AMCovS and cPACS patients.

Two independent observers analyzed the CMR findings in consensus. Cardiovascular damage was suspected clinically based on (i) symptoms such as chest pain, breathlessness, palpitation, arrhythmias, and dyspnea, (ii) hs-cTnT (high-sensitivity cardiac troponin T) level increase not meeting the criteria of myocardial infarction diagnosis, and (iii) abnormal electrocardiography (ECG) and/or echocardiography findings not suggestive of myocardial infarction.

Cine-SSFP (cine steady-state free precession) images were analyzed for assessing wall motion alterations and cardiac chambers’ function and volumes. STIR (short-tau inversion-recovery) and T2 images were analyzed to assess the extent of edema, and LGE (late gadolinium enhancement) images were analyzed for myocardial scar identification. Native T1 and post-contrast T1 images were analyzed to assess the extracellular volume fraction. The type and extent of cardiovascular alterations in the CMR images were reported.

Results

The study sample comprised 39 patients (17 and 22 AMCovS and cPACS patients, respectively), 62% (n=24) male. AMCovS patients were predominantly male (59%, n=10), the median patient age was 57.0 years, and had elevated hs-cTnT levels (median peak at 122 ng/L) related to acute pain in the chest (71%, n=12) with ST-T segment alterations (53%, n=9). Most patients (76%) had ≥1 comorbidity. Among AMCovS patients, 35% were intensive care unit (ICU)-admitted due to cardiogenic shock associated with ARDS (acute respiratory distress syndrome), or mild pneumonia.

In AMCovS patients, left ventricular (LV) systolic functioning was normal in 88% (n=15) of patients (LV-ejection fraction (EF) of 65%), and the median LV volume index values were normal. The right ventricular (RV) systolic functioning was normal in 94% (n=16) cases [right ventricular (RV)-EF of 63%), with normal values for the RV volume indices, except in one ICU-admitted patient with mild RV dilation (RV-end diastolic volume index (EDVi) value of 97.0 ml per square meter) and moderate RV systolic derangement (RV-EF of 40%) with LGE and diffuse-type edema of RV free wall, indicative of myocarditis. Histopathological examination yielded a diagnosis of necrotizing myocarditis for the patient.

Over 52% (n=9) of individuals showed myocarditis diagnosis criteria and focal-type edema in 78% (n=7) of patients, involving mainly the inferior part of the middle-basal wall and septum (67%, n=5). T2 images of all patients showed elevated values of 55 ms. In addition, all individuals (except for one patient) showed non-ischemic LGE involving the inferior wall and the septum (63%, n=5), with a minor scar burden affecting 1.0% of myocardial mass. In 24% (n=4) of patients, focal-type edema with ischemic LGE was observed in four myocardial segments, indicative of acute myocardial infarctions.

In the cPACS group, 22 individuals (64% male, median patient age was 38 years) underwent CMR imaging due to persistent cardiac symptoms such as dyspnea (45%, n=10) and recurring pain in the chest (55%, n=12). Ten individuals had a prior history of COVID-19-associated hospitalization with increased hs-cTnT levels among seven individuals (median peak at 238 ng/L) without any history of obstructive-type CAD (coronary artery disease). Over 58% of patients had ventricular arrhythmia. Other changes included wall motion alterations and ventricle dysfunction.

Among cPACS patients, CMR findings included active-type myocarditis, healed myocarditis, and pericarditis for 36% (n=8), 14% (n=3), and 9.0% (n=2) of patients, respectively. Over 26% (n=6) of patients were diagnosed with miscellaneous cardiomyopathies such as dilated cardiomyopathy (DCM), prolapse of the mitral valve with arrhythmogenic features, and myocardial non-compaction in three, two, and one patients, respectively. CMR findings were normal for three patients.

Six individuals with active-type myocarditis showed focal edema involving two segments, with greater T2 values of 55 ms. Non-ischemic LGE patterns were observed in the mid-basal wall on the lateral aspect (63% of cases, n=5) involving two myocardial segments with a 2.0% scar burden. The three individuals with healed myocarditis showed no edema, LGE in four inferior and lateral wall segments, and T2 values within the normal range.

Overall, the study findings showed that among individuals experiencing myocarditis-like symptoms in the acute and post-acute phases of COVID-19, CMR imaging enabled the non-invasive characterization of ischemic and non-ischemic cardiac damage and unraveled cardiomyopathies. Thus, the technique must be incorporated into the diagnostic workup of COVID-19 patients to enable personalized and advanced patient care and decrease the health burden of SARS-CoV-2 infections.

Tags: ACE2AngiotensinAngiotensin-Converting Enzyme 2CoronavirusCoronavirus Disease COVID-19CytokineDyspneaEdemaEnzymeHeartImagingInflammationMyocardial InfarctionMyocarditisOxygenPainPolymerasePolymerase Chain ReactionSARSSARS-CoV-2ScarSyndromeThrombosisTranscriptionUltrasound

Related Posts

Rare pancreatic cancer patients show remarkable outcomes with immunotherapy
Health

Rare pancreatic cancer patients show remarkable outcomes with immunotherapy

June 17, 2025
Disrupted biological rhythms in teens can produce unexpected brain effects
Health

Disrupted biological rhythms in teens can produce unexpected brain effects

June 17, 2025
Aging family physician workforce challenges primary care in Ontario
Health

Aging family physician workforce challenges primary care in Ontario

June 17, 2025
Supermarket ads push junk food for toddlers and infants
Health

Supermarket ads push junk food for toddlers and infants

June 17, 2025
Estrogen-responsive cells found to heighten gut pain in females
Health

Estrogen-responsive cells found to heighten gut pain in females

June 17, 2025
First patient treated in international clinical trial for rare muscle-weakness disease
Health

First patient treated in international clinical trial for rare muscle-weakness disease

June 16, 2025
Next Post
Montgomery calls for a Europe-wide PCR test requirement when entering from China

Montgomery calls for a Europe-wide PCR test requirement when entering from China

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

About

Sepoy.net is a perfect place for people who want daily updates on news related to business, technology, entertainment, health, cryptocurrency etc.

Contact: hello@sepoy.net

Major Categories

News

Business

Tech

Economy

 

Recent Posts

  • Enjoy online casino minimum deposit 4000 Real time Baccarat On the web
  • Hart Gambler Slot: Entdecke spannende Gewinnmöglichkeiten
  • Live Specialist Baccarat Listing of Better Alive miss kitty casino Agent Baccarat You On the web Gambling enterprises

Pages

  • About Us
  • Contact Us
  • Disclaimer
  • DMCA
  • Home
  • Privacy Policy

© 2023 Sepoy.net

No Result
View All Result
  • Home
  • Business
  • News
  • Health
  • Tech
  • Science
  • Lifestyle
  • Travel

© 2023 Sepoy.net