SEPOY.net
No Result
View All Result
Monday, June 16, 2025
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
  • Home
  • News
  • Business
  • Health
  • Tech
  • Lifestyle
  • Economy
  • Crypto
  • Travel
No Result
View All Result
SEPOY.NET
No Result
View All Result
Home Health

SARS-CoV-2 spike protein can lead to heart muscle injury through the inflammatory process

Nicholas by Nicholas
July 25, 2022
in Health
0

Heart damage is common among patients hospitalized with COVID-19, leading many to wonder how the virus affects the heart. Now, researchers have found that the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus can lead to heart muscle injury through the inflammatory process, according to preliminary research to be presented at the American Heart Association’s Basic Cardiovascular Sciences Scientific Sessions 2022. The meeting, held in Chicago on July 25-28, offers the latest research on basic and translational cardiovascular science.

READ ALSO

Paternal mental health found to impact child development

Two existing medications work effectively together in treating alcohol use disorder

The spike protein is found on the surface of SARS-CoV-2, the virus that causes COVID-19. Spike proteins latch onto receptors known as angiotensin-converting enzyme 2 (ACE2) on target cells. The spike protein facilitates virus entry into healthy cells, which is the first step in infection. In addition to infecting the lungs, the virus can also spread to other organs leading to more damage to the body, severe infection and, among some people, death.

It’s already known from the clinical side that COVID-19 infection can induce heart injury, however, what we don’t know is the mechanistic details of how this occurs. What we suspect is that the spike protein has unknown pathological rolesOur data show that the spike protein from SARS-CoV-2 causes heart muscle damage. That’s why it’s important to get vaccinated and prevent this disease.”


Zhiqiang Lin, Ph.D., lead author of the study and assistant professor, Masonic Medical Research Institute in Utica, New York

“Host natural immunity is the first line of defense against pathogen invasion, and heart muscle cells have their own natural immune machinery. Activation of the body’s immune response is essential for fighting against virus infection; however, this may also impair heart muscle cell function and even lead to cell death and heart failure,” Lin said.

The researchers studied whether the SARS-CoV-2 spike protein activates the natural immune response in heart muscle cells. HCoV-NL63 is a coronavirus that infects the respiratory system without causing cardiac injury, although its spike protein also uses ACE2 to mediate virus entry. They studied the potential ability to cause heart disease of both SARS-CoV-2 spike protein and the NL63 spike protein. Their results showed that the SARS-CoV-2 spike protein activated the natural immune response in heart muscle cells and damaged the heart, but the NL63 spike protein did not.

“The fact that the SARS-CoV-2 spike protein is activating the natural immune response may explain the high virulence compared to the other coronaviruses,” Lin said. “The TLR4 signaling is the major pathway that activates the body’s natural immune response, and the SARS-CoV-2 spike protein activates TLR4, not the regular flu spike protein.”

To investigate the impact of the SARS-CoV-2 spike protein on the heart, researchers cloned the SARS-CoV-2 spike protein and the NL63 spike protein into the AAV9 viral vector. The AAV9 viral vector was delivered into lab mice to activate the spike protein in the heart muscle cells. They found that the AAV9-mediated the SARS-CoV-2 spike protein, and not the NL63 spike protein, caused heart dysfunction, hypertrophic remodeling (enlargement) and cardiac inflammation.

In lab testing of heart cells cultured in dishes, researchers also observed that the SARS-CoV-2 spike protein made heart muscle cells much larger compared to cells without either spike protein. “We found direct evidence that the SARS-CoV-2 spike protein is toxic to heart muscle cells,” Lin said.

During this study, researchers also examined a heart biopsy from a deceased patient with inflammation due to COVID-19. They detected the SARS-CoV-2 spike protein and TLR4 protein in both heart muscle cells and other cell types. In contrast, these two proteins were absent in a biopsy of a healthy human heart. “That means once the heart is infected with SARS-CoV-2, it will activate the TLR4 signaling,” Lin said. “Besides directly damaging the heart muscle cells, the spike protein itself is very inflammatory and may cause systemic inflammation that indirectly causes heart problems.”

ACE2 is an important enzyme controlling blood pressure. SARS-CoV-2 infection may impair ACE2 function, which in turn leads to blood pressure increase and, thereby, injures the heart. SARS-CoV-2 may also damage the heart through other unknown pathways.

“Our study provides two pieces of evidence that the SARS-CoV-2 spike protein does not need ACE2 to injure the heart. First, we found that the SARS-CoV-2 spike protein injured the heart of lab mice. Different from ACE2 in humans, ACE2 in mice does not interact with SARS-CoV-2 spike protein, therefore, SARS-CoV-2 spike protein did not injure the heart by directly disrupting ACE2 function. Second, although both the SARS-CoV-2 and NL63 coronaviruses use ACE2 as a receptor to infect cells, only the SARS-CoV-2 spike protein interacted with TLR4 and inflamed the heart muscle cells. Therefore, our study presents a novel, ACE2-independent pathological role of the SARS-CoV-2 spike protein, ” Lin said.

This research takes the first step toward determining whether the SARS-CoV-2 spike protein affects the heart. The researchers now plan to investigate how SARS-CoV-2 spike proteins cause inflammation in the heart. There are two potential ways: the first is that spike protein is expressed in the virus-infected heart muscle cells and thereby directly activates inflammation; the second is that the virus spike protein is shed into the bloodstream, and the circulating SARS-CoV-2 spike proteins damage the heart.

Source:

American Heart Association

Tags: ACE2AngiotensinAngiotensin-Converting Enzyme 2BiopsyBloodBlood PressureCellCoronaviruscovid-19CTEnzymeHeartImmune ResponseimmunityInflammationLungsMedical ResearchmusclePathogenpHProteinResearchRespiratorySARSSARS-CoV-2Severe Acute RespiratorySevere Acute Respiratory SyndromeSpike ProteinSyndromeViral VectorVirus

Related Posts

Paternal mental health found to impact child development
Health

Paternal mental health found to impact child development

June 16, 2025
Two existing medications work effectively together in treating alcohol use disorder
Health

Two existing medications work effectively together in treating alcohol use disorder

June 16, 2025
FDA approval of pembrolizumab marks major shift in head and neck cancer treatment
Health

FDA approval of pembrolizumab marks major shift in head and neck cancer treatment

June 16, 2025
Health care employment rebounds after the pandemic but staffing gaps remain
Health

Health care employment rebounds after the pandemic but staffing gaps remain

June 16, 2025
Rapid generation of functional blood vessels from human stem cells
Health

Rapid generation of functional blood vessels from human stem cells

June 14, 2025
Cardiovascular deaths surge among less educated Americans
Health

Cardiovascular deaths surge among less educated Americans

June 14, 2025
Next Post

The Kremlin contradicts Scholz and threatens Selenskyj

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

About

Sepoy.net is a perfect place for people who want daily updates on news related to business, technology, entertainment, health, cryptocurrency etc.

Contact: hello@sepoy.net

Major Categories

News

Business

Tech

Economy

 

Recent Posts

  • Freispiele im Spielsaal, Erhalten Eltern Free Spins Slot big bang ohne Einzahlung
  • Finest tombola casino uk Roulette Sites United states 2025 Play Roulette the real deal Currency
  • Enjoy Casino poker On the web To Victory Dollars & Awards

Pages

  • About Us
  • Contact Us
  • Disclaimer
  • DMCA
  • Home
  • Privacy Policy

© 2023 Sepoy.net

No Result
View All Result
  • Home
  • Business
  • News
  • Health
  • Tech
  • Science
  • Lifestyle
  • Travel

© 2023 Sepoy.net